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Healthspan, decade by decade

Know what to test, what to track, and what is worth paying for.

Reference ranges, screening schedules and side-by-side comparisons for adults who already spend money on their health. Every number carries the source that sets it and the date we checked it.

Popular ALTApoBBPeGFR GLP-1 programs

Every range below was published by a named body. The line under each says how many documents set that marker's numbers, and when.

TSH 0.45 to 4.12mIU/L Reference interval (if your lab prints none) 2 sources, 2012 to 2016 eGFR 90 or highermL/min/1.73m² G1: normal or high (CKD only with damage markers) One source, published 2024 Hemoglobin A1C under 5.7% Normal (below the prediabetes range) 2 sources, published 2026

Guides

All guides →

Weight and metabolism 11 min read

Zepbound vs Wegovy: the head-to-head trial, the labels and the price

SURMOUNT-5 (NEJM, 2025) randomized 751 adults with obesity and no type 2 diabetes to tirzepatide or semaglutide at the maximum tolerated dose for 72 weeks: mean weight loss 20.2 percent against 13.7, waist 18.4 cm against 13.0. It was open-label and Lilly-funded. The labels share their core warnings, nausea led each drug's own trials, and neither label allows a cross-trial side-effect comparison. Cash: Zepbound KwikPen $299 to $699 a month by dose, $449 on 7.5 mg and up with refills within 45 days; Wegovy pen $199 for two new-patient fills, then $349 ($399 for 7.2 mg).

Photo: Annushka Ahuja / Pexels

New and updated

  1. Weight and metabolism · What happens when you stop Ozempic: the trials that measured it
  2. Weight and metabolism · Wegovy pill vs injection: what one label says about both
  3. Weight and metabolism · Ozempic cost without insurance in 2026: Novo's own prices, dose by dose
  4. Weight and metabolism · GLP-1 side effects: what the labels report, drug by drug
  5. Weight and metabolism · Does Ozempic cause hair loss? What the labels and the 2026 studies say

01  /  Explore by topic

Ten pillars of healthspan

Each hub collects the guides, the biomarkers to track and the services we have checked for one part of your health. Hubs open as their first guides publish.

02  /  Tools

Look it up

Biomarker lookup

What does my number mean?

Reference ranges from the body that sets them, drawn to scale.

A1C converter → All 21 biomarkers →

Decade checklist

What should I get checked?

Screening ledgers with the recommending body, grade, source and date on every row.

Look up by exact age →

Program comparison

Which GLP-1 program is worth it?

Prices, what is actually prescribed, and the vetting record, side by side.

18 services checked
Cost calculator Compare programs

03  /  What we recommend

Services we have checked, ranked

How we pick, and the record

We include products and services we think are useful. If you buy through links on this page, we may earn a commission. Here is how we pick.

At-home lab tests

4.0

Everlywell

Best for readers who want a baseline or a between-visit check on a specific marker and will take the result to a clinician.

Everlywell is a reasonable way to get a finger-prick A1C, lipid or testosterone number without a clinic visit, at $49 to $149 a test, with CLIA-lab processing and physician review. It is a screening tool, not a diagnosis, and it is not sold in New York.

HbA1c $49; cholesterol and lipids $49; heart health panel $99

Read our review Shop tests

Telehealth / primary care

4.0

Sesame

Best for uninsured or high-deductible readers who want an upfront price for a visit, or a lower-fee brand-only GLP-1 program.

Sesame is the honest budget option: transparent per-visit cash prices, clinicians in every state, and a weight-loss program that sells brand-name GLP-1s only. It does not bill insurance, so insured readers pay out of pocket for the visit.

Telehealth visits from $34; weight-loss program $99/mo or $59/mo annual

Read our review See visit prices

Weight management / GLP-1

3.3

Trimi

Best for cash payers set on a compounded GLP-1 who will prepay a longer plan and accept that these are not FDA-approved products.

Trimi undercuts every compounded program we checked ($99 to $175 a month for semaglutide) and names its prescriber network and pharmacies. Its own terms never name a legal entity, and one cited pharmacy license resolves to a different company name. Good price, read the fine print.

Compounded semaglutide from $99/mo on a 12-month prepay; $175 month to month

Read our review See plans

04  /  Health by decade

What changes, what to test, what to track, at your age

05  /  How we work

Four rules, enforced in the software

  • 01

    Every number has a source and a date

    A reference range or screening row cannot be saved without the primary document that sets it and that document's own date.

    See the library →

  • 02

    Services are checked before they appear

    Checked against FDA warning letters and import alerts, state actions and the terms of sale, on a recorded date. No check, no link.

    Read the record →

  • 03

    Compounded products are labeled, always

    A seller of compounded medicines carries a notice above every button, and never appears beside enforcement coverage.

    Our partner rule →

  • 04

    We say what we do not know

    "Unverified" and "the source publishes no total" appear on the page rather than a confident wrong figure.

    How we work →

Newsletter

One email a week. What to test, what to track, what it costs.

One biomarker explained, what changed in GLP-1 and lab pricing, and one guide worth your time. Every item sourced and dated; anything sponsored is labeled.

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